Weight Management Test

Weight Management Test

Weight Management Test

At-home collection kit. Meaningful insights. Personalized plan.
Discover how to reach your weight goal. This at-home blood and saliva test provides insights by measuring key biomarkers associated with weight management. Results include a personalized health plan.



Obesity is a growing epidemic. The average person gains 1.5 pounds of fat every year. The Centers for Disease Control and Prevention report that 40 percent of adults are obese, with the highest prevalence of obesity occurring in men and women older than 40. Your metabolism is directly affected by your hormone levels, dietary patterns, stress levels, and your ability to maintain physical activity, muscle mass, and optimal nutrition status.


Your body composition changes naturally over time because of fluctuating hormone levels associated with age. Thorne’s Weight Management test measures estrogen (in the form of estradiol), testosterone, DHEA-S, and progesterone ‐ all hormones that naturally decrease with age (except for estrogen levels in men, which tend to go up with age as testosterone goes down). These hormones, along with the other biomarkers in this test, are important regulators of body composition, including maintenance of muscle mass and changes in body fat accumulation, metabolism, and energy levels. An imbalance in one or more of these hormone levels could be sabotaging your ability to lose weight or maintain your current weight.

In addition to the sex hormones, the Weight Management Test measures thyroid stimulating hormone (TSH), a primary indicator of thyroid function. TSH stimulates the production of thyroid hormones T3 and T4, which are responsible for regulating the speed at which cells work ‐ everything from how fast your heart beats to how fast your intestines process food. An underactive thyroid gland slows down your body’s metabolism, which decreases energy production and contributes to weight gain. Progesterone levels also play a role in thyroid function.

Insulin Resistance

Thorne’s Weight Management test measures insulin and hemoglobin A1C (HbA1c), two biomarkers of carbohydrate tolerance and blood sugar management. When you consume sugar, the hormone insulin is released from your pancreas to take that sugar from the bloodstream into your cells to be used for energy. Any extra sugar is stored and converted into body fat. Type 2 diabetes occurs as a result of insulin resistance ‐ the inability to use insulin effectively or make enough insulin ‐ which results in elevated blood glucose levels. Being overweight can increase your risk of becoming insulin resistant or having an elevated level of blood sugar. And on the flipside, a high insulin level can contribute to you being overweight.

HbA1c is a measure of your overall blood sugar control and can be used as a marker of risk for diabetes. The HbA1c test measures your average blood sugar during the past three-month period by measuring the amount of hemoglobin in your blood that has glucose attached to it. Having higher average blood sugar levels over time will result in an elevated HbA1c level. An elevated HbA1c increases your risk for insulin resistance, diabetes, and cardiovascular disease.

Vitamin D

Vitamin D has always been known for its capacity to support calcium absorption and bone health. More recently, an understanding of its wider role in the body has emerged, which includes healthy immune function, maintaining a normal inflammatory response, supporting muscle structure and function, and support for weight management. Overweight individuals tend to have a lower vitamin D level because vitamin D can be sequestered in body fat, and the ability to maintain higher vitamin D levels is associated with weight loss. Although the sun is a primary source of vitamin D for humans, we don’t get as much sun as our ancestors did, which puts us at risk for lower levels. A chronically lower level of vitamin D is also associated with a higher risk for diseases such as heart disease and cancer.


Cortisol is a hormone made in your adrenal glands. It is often called “the stress hormone” because your body releases more cortisol when you are experiencing stress, are ill, or have a low blood sugar level. Cortisol levels fluctuate naturally during the day, with the highest level usually being in the morning to help you wake up, to enhance your energy and appetite, and to moderate your normal response to physical and emotional stress during the day. When your cortisol levels are altered, a wide variety of adverse health effects can be experienced, including mood changes, energy changes, altered immune function, and weight changes.

What the tests tell you

Biomarker values
Simple visualization of your biomarker results over time, plus detailed descriptions of each biomarker for an easy interpretation of your overall health.

Health analysis
Insights based on your results help you identify potential health risks or areas of improvement.

Personalized plan
Access your diet, activity, and supplement plan anytime, anywhere through the Thorne dashboard. Recommendations are generated from our medically-supervised algorithms based on your unique test results.

Potential Symptoms

Symptoms attributed to the need for better weight management include:

Easy weight gain or difficulty losing weight
Decreases in lean muscle mass
Increases in abdominal fat
Food or sugar cravings
Poor tolerance for exercise
Difficulty sleeping or anxiety in the evening (which can contribute to weight gain)

How it works

1 Delivered
After purchasing, all home-test materials are delivered to your door

2 Locate Barcode
Locate the barcode included with your kit and enter at thorne.com

3 Complete Collection
Complete your test collection and return with prepaid shipping

4 Reviewed
Your results are reviewed by an independent board-certified physician

5 Receive Results
You’ll receive your results & personalized recommendations within 7-9 days

Biomarkers Measured

Estradiol – Saliva
Normal range varies by gender
Estradiol is the most powerful and active form of estrogen in the body. In addition to being important for bone health, fertility, and cardiovascular healthy, estradiol plays a role in how the body regulates weight and metabolism.

Progesterone – Saliva
Normal range varies by gender
In women, progesterone is a hormone released by the ovaries during ovulation. It is also produced to a lesser extent in the adrenal glands. In men, progesterone is produced in the testes and adrenal glands. An altered progesterone level can result in bloating and food cravings. The level of progesterone is also connected to thyroid function and the conversion of fat into energy.

Testosterone – Saliva
Normal range varies based on age and gender
Testosterone is the predominant androgen or “male hormone” – although it is important to the health of both men and women. A normal testosterone level is important for maintaining lean body mass and healthy body composition.

DHEA – Saliva
Normal range varies based on age and gender
Dehydroepiandrosterone sulfate is produced in the adrenal glands, and it can be converted to testosterone and estrogen in other tissues. DHEA-S balances the effect of cortisol on metabolism and might be especially important for age-related weight maintenance.

Cortisol – Saliva
Normal range varies throughout the day
Cortisol is a hormone secreted by the adrenal glands. Cortisol has wide-ranging effects on regulating metabolism, immune function, and the body’s response to stress. An abnormal level of cortisol can have an adverse effect on appetite and body weight.

TSH – Blood Spot
Normal range is 0.5 – 3.0 μU/mL
Thyroid Stimulating Hormone is a hormone secreted by the pituitary gland that stimulates production of T4 and T3 hormones in the thyroid gland. An abnormal level of TSH is often the first sign of thyroid dysfunction and can contribute to problems with body weight and metabolism.

Insulin – Blood Spot
Normal range is 1.0 – 15.0 μIU/mL
Insulin is a hormone that helps regulate blood glucose levels. A healthy insulin level is associated with better metabolic health. An abnormal level of insulin is often associated with weight gain and/or a difficult time losing weight.

HbA1c – Blood Spot
Normal range is < 5.7 %
Hemoglobin A1c is a biomarker that tells you about your average blood sugar level during the past 90 days. Maintaining an HbA1c level in the normal range is associated with better metabolic health and better control of body weight.

Vitamin D – Blood Spot
Normal range varies on many factors
Vitamin D is a fat-soluble vitamin that we obtain from some foods or make in our bodies under the right conditions. A healthy vitamin D level is important for normal metabolism. A low level of vitamin D is tied to overweight, obesity, and poor metabolic health.

You should take this test if you:

Are having difficulty controlling your weight
Experience persistent stress (that can influence weight)
Want to understand how your hormones are related to your weight
Don’t feel rested after sleeping
Feel sluggish and fatigued
Have frequent sugar cravings